Medicinal Chemistry into the Millenium
نویسندگان
چکیده
منابع مشابه
Transforming fragments into candidates: small becomes big in medicinal chemistry.
Fragment-based drug discovery (FBDD) represents a logical and efficient approach to lead discovery and optimisation. It can draw on structural, biophysical and biochemical data, incorporating a wide range of inputs, from precise mode-of-binding information on specific fragments to wider ranging pharmacophoric screening surveys using traditional HTS approaches. It is truly an enabling technology...
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In this paper we report the synthesis of three families of new amidine–based aromatic derivatives as potential DNA minor groove binding agents for the treatment of cancer. The preparation of mono–guanidine, mono–2–aminoimidazoline and asymmetric diphenyl guanidine/2–aminoimidazoline derivatives (compounds 1a,b,c to 8a,b,c) is presented. The affinity of these substrates and of a family of mono– ...
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ژورنال
عنوان ژورنال: Synthesis
سال: 2004
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-2002-19790